7. Applications of Design Space for Biopharmaceutical Purification Processes

  1. Anurag S. Rathore1 and
  2. Rohin Mhatre2
  1. Douglas J. Cecchini

Published Online: 28 OCT 2008

DOI: 10.1002/9780470466315.ch7

Quality by Design for Biopharmaceuticals: Principles and Case Studies

Quality by Design for Biopharmaceuticals: Principles and Case Studies

How to Cite

Cecchini, D. J. (2008) Applications of Design Space for Biopharmaceutical Purification Processes, in Quality by Design for Biopharmaceuticals: Principles and Case Studies (eds A. S. Rathore and R. Mhatre), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470466315.ch7

Editor Information

  1. 1

    Amgen Inc., Thousand Oaks, California, USA

  2. 2

    Biogen Idec, Cambridge, Massachusetts, USA

Author Information

  1. Biogen Idec, Cambridge, Massachusetts, USA

Publication History

  1. Published Online: 28 OCT 2008
  2. Published Print: 8 JUN 2009

ISBN Information

Print ISBN: 9780470282335

Online ISBN: 9780470466315

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Keywords:

  • design space applications for biopharmaceutical purification;
  • design space for purification processes in process development;
  • cell harvest and product capture steps

Summary

This chapter contains sections titled:

  • Introduction

  • Establishing Design Space for Purification Processes during Process Development

  • Applications of Design Space

  • Cell Harvest and Product Capture Steps

  • Protein A Capture Column

  • Hydrophobic Interaction Chromatography

  • Anion Exchange Chromatography

  • Summary

  • Acknowledgments

  • References