Published Online: 30 JAN 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Corsini Encyclopedia of Psychology
How to Cite
Krippner, S. 2010. Psychoneuroimmunology. Corsini Encyclopedia of Psychology. 1–2.
- Published Online: 30 JAN 2010
Psychoneuroimmunology (PNI) can be defined as the study of adaptive interactions among the behavioral, neurological, endocrinal, and immunological systems. PNI emerged from the realization that the immune system does not operate autonomously, as had been assumed by those who had conceptualized it as a closed system. This former perspective assumed the immune system was driven by challenges from foreign substances (antigens) and was regulated by soluble products that were produced and released by immune cells (e.g., lymphokines, cytokines, monokines). Although antigens do initiate immune responses, and cytokines (such as interleukin-1) do regulate immune processes, data now demonstrate that there are bidirectional communication pathways between the immune system and the central nervous system (CNS), with each providing important regulatory control over the other (Maier, Watkins, & Fleshner, 1994).
- bodily defenses;
- immunoregulatory processes;
- origins of psychoneuroimmunology