3. ABCG2: A New Challenge in Cancer Drug Resistance

  1. Ahcène Boumendjel4,
  2. Jean Boutonnat5,6 and
  3. Jacques Robert7
  1. Orsolya Polgar1,
  2. Robert W. Robey1,
  3. Kin Wah To1,
  4. John Deeken2,
  5. Patricia A. Fetsch3 and
  6. Susan E. Bates1

Published Online: 15 JUN 2009

DOI: 10.1002/9780470495131.ch3

ABC Transporters and Multidrug Resistance

ABC Transporters and Multidrug Resistance

How to Cite

Polgar, O., Robey, R. W., To, K. W., Deeken, J., Fetsch, P. A. and Bates, S. E. (2009) ABCG2: A New Challenge in Cancer Drug Resistance, in ABC Transporters and Multidrug Resistance (eds A. Boumendjel, J. Boutonnat and J. Robert), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470495131.ch3

Editor Information

  1. 4

    Université de Grenoble, Grenoble, France

  2. 5

    Institut Jean Roget, Université Joseph Fourier, Grenoble, France

  3. 6

    Hôpital Michallon de Grenoble, Grenoble, France

  4. 7

    Institut Bergonié, Université Victor Segalen, Bordeaux, France

Author Information

  1. 1

    Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

  2. 2

    Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC, USA

  3. 3

    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

Publication History

  1. Published Online: 15 JUN 2009
  2. Published Print: 13 JUL 2009

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470227343

Online ISBN: 9780470495131

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Keywords:

  • ABCG2 - cancer drug resistance challenge;
  • substrates and inhibitors of ABCG2-mediated transport;
  • ABCG2 expression in cancer and putative role in drug resistance

Summary

This chapter contains sections titled:

  • Introduction

  • Chromosomal localization and mechanisms controlling expression

  • Tissue localization

  • Substrates and inhibitors of ABCG2-mediated transport

  • Structure of the ABCG2 protein

  • Single nucleotide polymorphisms

  • Expression of ABCG2 in cancer and its putative role in drug resistance

  • ABCG2 expression and the cancer stem cell

  • Avoiding the mistakes of the past in the development of ABCG2 inhibitors

  • References