5. ABC Proteins and Oncology: Expression, Detection, and Implication of ABC Proteins in Solid Tumors

  1. Ahcène Boumendjel3,
  2. Jean Boutonnat4,5 and
  3. Jacques Robert6
  1. Jean François Bernaudin1,
  2. Anne Fajac1,
  3. Jocelyne Fleury-Feith1,
  4. Khaldoun Kerrou2 and
  5. Roger Lacave1

Published Online: 15 JUN 2009

DOI: 10.1002/9780470495131.ch5

ABC Transporters and Multidrug Resistance

ABC Transporters and Multidrug Resistance

How to Cite

Bernaudin, J. F., Fajac, A., Fleury-Feith, J., Kerrou, K. and Lacave, R. (2009) ABC Proteins and Oncology: Expression, Detection, and Implication of ABC Proteins in Solid Tumors, in ABC Transporters and Multidrug Resistance (eds A. Boumendjel, J. Boutonnat and J. Robert), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470495131.ch5

Editor Information

  1. 3

    Université de Grenoble, Grenoble, France

  2. 4

    Institut Jean Roget, Université Joseph Fourier, Grenoble, France

  3. 5

    Hôpital Michallon de Grenoble, Grenoble, France

  4. 6

    Institut Bergonié, Université Victor Segalen, Bordeaux, France

Author Information

  1. 1

    Laboratory of Histology and Tumor Biology, University Pierre and Marie Curie Paris VI, Hôpital Tenon APHP, Paris, France

  2. 2

    Nuclear Medicine Department, Hôpital Tenon, Paris, France

Publication History

  1. Published Online: 15 JUN 2009
  2. Published Print: 13 JUL 2009

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470227343

Online ISBN: 9780470495131

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Keywords:

  • anticancer drugs - ABC transporter substrates;
  • ABC proteins and oncology;
  • host and pharmacogenetics of ABC transporters and solid tumors

Summary

This chapter contains sections titled:

  • Introduction

  • Anticancer drugs that are substrates of ABC transporters

  • Detection of MDR-related ABC transporters in solid tumor samples

  • The cellular and tissue ABC transporter expression in solid tumors

  • The host: Pharmacogenetics of ABC transporters and solid tumors

  • Clinical relevance of ABC transporter detection in solid tumors

  • Conclusion

  • References