Antidepressant-Binding Sites in Brain and Platelets

  1. Ruth Porter Organizer,
  2. Gregory Bock Organizer and
  3. Sarah Clark
  1. S.Z. Langer,
  2. A.M. Galzin,
  3. C.R. Lee and
  4. H. Schoemaker

Published Online: 28 SEP 2007

DOI: 10.1002/9780470513361.ch2

Ciba Foundation Symposium 123 - Antidepressants and Receptor Function

Ciba Foundation Symposium 123 - Antidepressants and Receptor Function

How to Cite

Langer, S.Z., Galzin, A.M., Lee, C.R. and Schoemaker, H. (2007) Antidepressant-Binding Sites in Brain and Platelets, in Ciba Foundation Symposium 123 - Antidepressants and Receptor Function (eds R. Porter, G. Bock and S. Clark), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470513361.ch2

Author Information

  1. Department of Biology, Laboratoires d' Etudes et de Recherches Synthélabo (L.E.R.S.), 58 rue de la Glacière, 75013 Paris, France

Publication History

  1. Published Online: 28 SEP 2007

ISBN Information

Print ISBN: 9780471910893

Online ISBN: 9780470513361

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Keywords:

  • antidepressantbinding sites;
  • serotonin transporter;
  • endocoids;
  • depression;
  • pathogenesis

Summary

[3H]Irnipramine and [3H]paroxetine label with high affinity a site associated with the serotonin transporter in brain and platelets. The maximum binding capacity (Bmax) of [3H]imipramine in platelets is reduced in untreated depressed patients, and it may represent a useful biological marker in depression. The existence of an endogenous ligand acting on the [3H]imipramine-recognition site to modulate the serotonin transporter has been proposed by several laboratories. 5-Methoxytryptoline inhibits [3H]imipramine binding and [3H]serotonin uptake in the nanomolar range. This compound has been reported to occur in the pineal gland, but probably only in trace amounts. While the physiological relevance of 5-methoxytryptoline or a close analogue remains an open question, the possibility exists that the ‘endocoid’ for the [3H]imipramine-recognition site plays a role in the pathogenesis of depression.