Alzheimer's Disease as an Age-Dependent Disorder

  1. David Evered Organizer and
  2. Julie Whelan
  1. Robert Katzman

Published Online: 28 SEP 2007

DOI: 10.1002/9780470513583.ch6

Ciba Foundation Symposium 134 - Research and the Ageing Population

Ciba Foundation Symposium 134 - Research and the Ageing Population

How to Cite

Katzman, R. (2007) Alzheimer's Disease as an Age-Dependent Disorder, in Ciba Foundation Symposium 134 - Research and the Ageing Population (eds D. Evered and J. Whelan), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470513583.ch6

Author Information

  1. Department of Neurosciences, School of Medicine (M-024), University of California, San Diego, La Jolla, California 92093, USA

Publication History

  1. Published Online: 28 SEP 2007

ISBN Information

Print ISBN: 9780471914204

Online ISBN: 9780470513583

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Keywords:

  • alzheimer's disease;
  • age-dependent disorder;
  • neuropsychological manifestations;
  • cognitive impairment;
  • new york city

Summary

Alzheimer's disease is the most significant of the age-related diseases of the brain. The incidence of Alzheimer's at age 80 is twenty-fold that at age 60 years. In one study the incidence at age 80 surpassed that of stroke. Three major advances have occurred in regard to Alzheimer's disease: (1) clinical diagnosis has markedly improved and now approaches 90% accuracy; (2) understanding of the biology of Alzheimer's has increased with delineation of specific fibrous protein abnormalities and identification of the amyloid precursor gene and the gene linked to familial Alzheimer's, both genes being located on chromosome 21; and (3) there have been advances in the correlation of specific nerve cell involvement and neurotransmitter changes with physiological (positron emission tomography), behavioural and neuropsychological manifestations.