The Clinical Neurology and Epidemiology of Creutzfeldt-Jakob Disease, with Special Reference to Iatrogenic Cases

  1. Greg Bock Organizer and
  2. Joan Marsh
  1. Paul Brown

Published Online: 28 SEP 2007

DOI: 10.1002/9780470513613.ch2

Ciba Foundation Symposium 135 - Novel Infectious Agents and the Central Nervous System

Ciba Foundation Symposium 135 - Novel Infectious Agents and the Central Nervous System

How to Cite

Brown, P. (2007) The Clinical Neurology and Epidemiology of Creutzfeldt-Jakob Disease, with Special Reference to Iatrogenic Cases, in Ciba Foundation Symposium 135 - Novel Infectious Agents and the Central Nervous System (eds G. Bock and J. Marsh), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470513613.ch2

Author Information

  1. Nervous System Studies Laboratory, NINCDS, Building 36, Room 5B 21, National Institutes of Health, Bethesda, Maryland 20892, USA

Publication History

  1. Published Online: 28 SEP 2007

ISBN Information

Print ISBN: 9780471915126

Online ISBN: 9780470513613

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Keywords:

  • clinical neurology;
  • epidemiology;
  • creutzfeld-jakob disease (cjd);
  • hypopituitary dwarfs;
  • human pituitary glands

Summary

The clinical characteristics of Creutzfeldt-Jakob disease (CJD) in a newly analysed group of 223 cases transmitted to primates at the NIH are compared to a recent large series of neuropathologically verified cases in France, and the limited conclusions from worldwide epidemiological studies are briefly summarized. Discussion then focuses on iatrogenic CJD, with special attention to the interplay of clinical, laboratory and epidemiological features of the current outbreak of CJD in hypopituitary dwarfs treated with growth hormone extracted from pools of human pituitary glands.