Scrapie: A Virus-Induced Amyloidosis of the Brain

  1. Greg Bock Organizer and
  2. Joan Marsh
  1. Heino Diringer,
  2. Henk Ronald Braig and
  3. Markus Czub

Published Online: 28 SEP 2007

DOI: 10.1002/9780470513613.ch9

Ciba Foundation Symposium 135 - Novel Infectious Agents and the Central Nervous System

Ciba Foundation Symposium 135 - Novel Infectious Agents and the Central Nervous System

How to Cite

Diringer, H., Braig, H. R. and Czub, M. (2007) Scrapie: A Virus-Induced Amyloidosis of the Brain, in Ciba Foundation Symposium 135 - Novel Infectious Agents and the Central Nervous System (eds G. Bock and J. Marsh), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470513613.ch9

Author Information

  1. Department of Biochemistry, Robert Koch Institut des Bundesgesundheitsamtes, Nordufer 20, D-1000 Berlin 65, Federal Republic of Germany

Publication History

  1. Published Online: 28 SEP 2007

ISBN Information

Print ISBN: 9780471915126

Online ISBN: 9780470513613

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Keywords:

  • scrapie;
  • pathogenesis;
  • brain-specific amyloidosis;
  • creutzfeldt-jakob disease;
  • mink encephalopathy

Summary

We have studied the pathogenesis of scrapie in hamsters, in particular the increase of infectivity and the formation of scrapie-associated fibrils in relation to clinical disease. The results of such studies after intraperitoneal or intracerebral infection are consistent with the idea that transmissible spongiform encephalopathies are a type of virus-induced, brain-specific amyloidosis. Therefore, an appropriate name for the class of viruses that cause these diseases might be amyloid-inducing viruses.