IgE and Inflammatory Cells

  1. Derek J. Chadwick Organizer,
  2. David Evered Organizer and
  3. Julie Whelan
  1. A. Capron1,2,
  2. M. Capron1,
  3. C. Grangette1 and
  4. J. P. Dessaint1

Published Online: 28 SEP 2007

DOI: 10.1002/9780470513866.ch10

Ciba Foundation Symposium 147 - IgE, Mast Cells and the Allergic Response

Ciba Foundation Symposium 147 - IgE, Mast Cells and the Allergic Response

How to Cite

Capron, A., Capron, M., Grangette, C. and Dessaint, J. P. (2007) IgE and Inflammatory Cells, in Ciba Foundation Symposium 147 - IgE, Mast Cells and the Allergic Response (eds D. J. Chadwick, D. Evered and J. Whelan), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470513866.ch10

Author Information

  1. 1

    Centre d'Immunologie et de Biologie Parasitaire, Unite Mixte INSERM U167-CNRS 624, Institut Pasteur, Lille, France

  2. 2

    Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur, 1 rue du Professeur A. Calmette, BP 245, F-59019 Lille Cedex, France

Publication History

  1. Published Online: 28 SEP 2007

ISBN Information

Print ISBN: 9780471923091

Online ISBN: 9780470513866

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Keywords:

  • IgE;
  • inflammatory cells;
  • eosinophil IgE receptors;
  • adhesion sequence;
  • cell activation

Summary

Extensive studies initiated in parasitic disease models have unequivocally established that IgE antibodies can directly interact with mononuclear phagocytes, eosinophils and platelets through specific surface receptors now identified as FcεRII. Genes coding for B cell and more recently eosinophil IgE receptors have been cloned. Studies on molecular structure indicate a close homology between FcεRII on inflammatory cells and on B cells but indications are emerging of some degree of heterogeneity among the second class of receptors for IgE. Recent studies performed in parallel on eosinophils indicate that their IgE receptors contain a sequence commonly involved in the primary structure of adhesion proteins. Interaction between antigen and cytophilically bound IgE antibodies results in the triggering of cell effector function and the release of a variety of pro-inflammatory or cytocidal mediators. Among others, one eosinophil granule protein (eosinophil peroxidase) is preferentially released by anaphylactic isotype-dependent stimuli. The main expression of IgE-dependent platelet activation appears related to the production of oxygen-derived free radicals (detected by chemoluminescence and electron magnetic resonance) together with their cytocidal properties. Taken together these findings confirm our current view that IgE receptors on inflammatory cells play a major role in the expression of cell effector function, both in defence mechanisms against several parasites and in allergic reactions.