Molecular Pharmacology of Cocaine: A Dopamine Hypothesis and its Implications

  1. Gregory R. Bock Organizer and
  2. Julie Whelan
  1. Michael J. Kuhar

Published Online: 28 SEP 2007

DOI: 10.1002/9780470514245.ch6

Ciba Foundation Symposium 166 - Cocaine: Scientific and Social Dimensions

Ciba Foundation Symposium 166 - Cocaine: Scientific and Social Dimensions

How to Cite

Kuhar, M. J. (2007) Molecular Pharmacology of Cocaine: A Dopamine Hypothesis and its Implications, in Ciba Foundation Symposium 166 - Cocaine: Scientific and Social Dimensions (eds G. R. Bock and J. Whelan), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470514245.ch6

Author Information

  1. Neuroscience Branch, Addiction Research Center, National Institute on Drug Abuse, P.O. Box 5180, Baltimore, MD 21224, USA

Publication History

  1. Published Online: 28 SEP 2007

ISBN Information

Print ISBN: 9780471931799

Online ISBN: 9780470514245

SEARCH

Keywords:

  • molecular pharmacology;
  • cocaine receptor;
  • dopamine hypothesis;
  • human drug dependence;
  • hydrogen-labelled dopamine

Summary

The reinforcing properties of cocaine have been related to cocaine binding at the dopamine transporter in mesolimbocortical neurons. The molecular properties of the transporter have been studied in a number of laboratories. While this ‘dopamine hypothesis’ is strongly supported in animal studies of drug self-administration, the extent of its involvement in human drug dependence has not been fully elucidated.