Activation of MPF in Fission Yeast

  1. Joan Marsh
  1. Jonathan B. A. Millar,
  2. Guy Lenaers,
  3. Clare McGowan and
  4. Paul Russell

Published Online: 28 SEP 2007

DOI: 10.1002/9780470514320.ch5

Ciba Foundation Symposium 170 - Regulation of the Eukaryotic Cell Cycle

Ciba Foundation Symposium 170 - Regulation of the Eukaryotic Cell Cycle

How to Cite

Millar, J. B. A., Lenaers, G., McGowan, C. and Russell, P. (2007) Activation of MPF in Fission Yeast, in Ciba Foundation Symposium 170 - Regulation of the Eukaryotic Cell Cycle (ed J. Marsh), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470514320.ch5

Author Information

  1. Departments of Molecular and Cell biology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA

Publication History

  1. Published Online: 28 SEP 2007

ISBN Information

Print ISBN: 9780471934462

Online ISBN: 9780470514320

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Keywords:

  • fission yeast activation;
  • structure-function relationships;
  • dephosphorylation;
  • fission yeast protein;
  • MPF regulation

Summary

In fission yeast p34cdc2/cyclin is activated at the G2/M boundary by dephosphorylation of Tyr 15 of the p34cdc2 subunit. Two protein phosphatases carry out this dephosphorylation event. The major activity is encoded by cdc25, which is a distantly related member of the protein tyrosine phosphatase family. A minor activity is provided by a newly identified fission yeast protein tyrosine phosphatase.