Molecular Genetics of Neurulation

  1. Gregory Bock and
  2. Joan Marsh
  1. Nancy Papalopulu and
  2. Chris R. Kintner

Published Online: 28 SEP 2007

DOI: 10.1002/9780470514559.ch6

Ciba Foundation Symposium 181 - Neural Tube Defects

Ciba Foundation Symposium 181 - Neural Tube Defects

How to Cite

Papalopulu, N. and Kintner, C. R. (2007) Molecular Genetics of Neurulation, in Ciba Foundation Symposium 181 - Neural Tube Defects (eds G. Bock and J. Marsh), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470514559.ch6

Author Information

  1. Molecular Neurobiological Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, PO Box 85800, San Diego, CA 92186-5800, USA

Publication History

  1. Published Online: 28 SEP 2007

ISBN Information

Print ISBN: 9780471941729

Online ISBN: 9780470514559

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Keywords:

  • molecular genetics;
  • neurulation;
  • differential expression;
  • gene expression;
  • neural tube formation

Summary

The formation of the neural tube begins during gastrulation when ectoderm, an epithelial sheet on the outside of the embryo, is induced to form the neural plate. During the process of neural induction, the epithelium of the neural plate is regionalized along both the dorsoventral and anteroposterior axes of the embryo; this regionalization is likely to contribute to the cellular processes underlying neurulation. Genes whose expression marks the formation and regionalization of the neural plate and which encode cell adhesion molecules or putative transcription factors have been recently identified. The differential expression of these genes apparently subdivides the epithelium of the neural plate into small regions. Evidence from transgenic embryo experiments supports the idea that the differential expression of these genes in the neural plate plays a role in neural tube formation.