Factors that are Critical for Plasticity in the Visual Cortex

  1. Gregory R. Bock Organizer and
  2. Gail Cardew
  1. N. W. Daw,
  2. S. N. M. Reid,
  3. X.-F. Wang and
  4. H. J. Flavin

Published Online: 28 SEP 2007

DOI: 10.1002/9780470514795.ch13

Ciba Foundation Symposium 193 - Development of the Cerebral Cortex

Ciba Foundation Symposium 193 - Development of the Cerebral Cortex

How to Cite

Daw, N. W., Reid, S. N. M., Wang, X.-F. and Flavin, H. J. (2007) Factors that are Critical for Plasticity in the Visual Cortex, in Ciba Foundation Symposium 193 - Development of the Cerebral Cortex (eds G. R. Bock and G. Cardew), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470514795.ch13

Author Information

  1. Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, PO Box 208061, New Haven, CT 06520–8061, USA

Publication History

  1. Published Online: 28 SEP 2007

ISBN Information

Print ISBN: 9780471957058

Online ISBN: 9780470514795

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Keywords:

  • plasticity;
  • visual cortex;
  • retina;
  • metabotropic glutamate receptors;
  • putative factors

Summary

Factors that may be critical for plasticity in the visual cortex are evaluated according to three criteria. (1) Do antagonists to the factor abolish plasticity? (2) Does the concentration or activity of the factor peak with the critical period for plasticity? (3) Does rearing in the dark, which postpones the critical period, affect the factor in a similar fashion? N-methyl-D-aspartate receptors fulfil all three criteria. Metabotropic glutamate receptors fulfil two of them. Most other putative factors do not fulfil more than one.