The Generation of Cellular Diversity in the Cerebral Cortex

  1. Gregory R. Bock Organizer and
  2. Gail Cardew
  1. Jack Price1,
  2. Brenda P. Williams2 and
  3. Magdalena Götz1

Published Online: 28 SEP 2007

DOI: 10.1002/9780470514795.ch4

Ciba Foundation Symposium 193 - Development of the Cerebral Cortex

Ciba Foundation Symposium 193 - Development of the Cerebral Cortex

How to Cite

Price, J., Williams, B. P. and Götz, M. (2007) The Generation of Cellular Diversity in the Cerebral Cortex, in Ciba Foundation Symposium 193 - Development of the Cerebral Cortex (eds G. R. Bock and G. Cardew), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470514795.ch4

Author Information

  1. 1

    SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex CM19 5AW, UK

  2. 2

    Boston Biomedical Research Institute, Boston, Mass, USA

Publication History

  1. Published Online: 28 SEP 2007

ISBN Information

Print ISBN: 9780471957058

Online ISBN: 9780470514795

SEARCH

Keywords:

  • cellular diversity;
  • cerebral cortex;
  • cell culture;
  • oligodendrocytes;
  • gliogenesis

Summary

We have used retroviral vectors to study cell lineage in the embryonic rat cerebral cortex both in vivo and in dissociated cell culture. We provide evidence that during the late phase of corticogenesis, most precursor cells of the ventricular zone are specified for the production of a single cell type, either neurons or one of the glial cell types. Although specified, the precursor cells that generate neurons can apparently generate both pyramidal and non-pyramidal cells. Earlier stages of development are dominated by a different type of precursor cell with a number of properties that lead us to believe that it is the founding, multipotential precursor cell of the cerebral cortex. We discuss a possible model of cell lineage which unifies these various observations.