Neurotrophic Factors as Pharmacological Agents for the Treatment of Injured Auditory Neurons

  1. Gregory R. Bock Organizer and
  2. Jamie A. Goode
  1. Thomas R. Van De Water1,2,3,
  2. Hinrich Staecker1,3,
  3. Patrik Ernfors4,
  4. Gustave Moonen3 and
  5. Philippe P. Lefebvre1,2,5

Published Online: 28 SEP 2007

DOI: 10.1002/9780470514863.ch11

Ciba Foundation Symposium 196 - Growth Factors as Drugs for Neurological and Sensory Disorders

Ciba Foundation Symposium 196 - Growth Factors as Drugs for Neurological and Sensory Disorders

How to Cite

Van De Water, T. R., Staecker, H., Ernfors, P., Moonen, G. and Lefebvre, P. P. (2007) Neurotrophic Factors as Pharmacological Agents for the Treatment of Injured Auditory Neurons, in Ciba Foundation Symposium 196 - Growth Factors as Drugs for Neurological and Sensory Disorders (eds G. R. Bock and J. A. Goode), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470514863.ch11

Author Information

  1. 1

    Department of Otolaryngology, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA

  2. 2

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA

  3. 3

    Department of Human Physiology and Pathophysiology, University of Liège B4060, Liège, Belgium

  4. 4

    Department of Medical Chemistry, Laboratory of Molecular Neurobiology Doktorsringen 12A, Karolinska Institutet, 17177 Stockholm, Sweden

  5. 5

    Department of Otolaryngology and Audiophonology, University of Liège B4060, Liège, Belgium

Publication History

  1. Published Online: 28 SEP 2007

ISBN Information

Print ISBN: 9780471957218

Online ISBN: 9780470514863

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Keywords:

  • neurotrophic factors;
  • pharmacological agents;
  • injured auditory neurons;
  • fibroblast growth factors;
  • chick-quail interspecies transplants

Summary

Mature auditory neurons degenerate in response to a loss of target-derived trophic factors. Neurotrophic factors influence the health and viability of auditory neurons. This suggests that neurotrophic factors can be used as therapeutic agents to prevent neuronal cell death and to initiate repair of damaged neuronal processes in the injured auditory system. Both in vitro and in vivo experiments have been performed to determine which of the vast array of neurotrophic factors affect mature auditory neurons and how they can be delivered to the sites of injury within the auditory system. Neurotrophin 3 was found to be a major survival factor for auditory neurons. Brain-derived neurotrophic factor is a minor survival factor for auditory neurons and nerve growth factor, although not promoting survival, does elicit the repair of neuronal processes. Fibroblast growth factor 2, transforming growth factor β1 and ciliary neurotrophic factor function as injury-response factors in the auditory system. Combination of different classes of growth factors has an additive effect on neuronal survival. Growth factors may be able to be delivered to sites of injury within the cochlea by either direct perfusion or gene therapy (e.g. a defective virus expressing a growth factor gene).