The Problems of Delivering Neuroactive Molecules to the CNS

  1. Gregory R. Bock Organizer and
  2. Jamie A. Goode
  1. Sanda A. Tan and
  2. Patrick Aebischer

Published Online: 28 SEP 2007

DOI: 10.1002/9780470514863.ch14

Ciba Foundation Symposium 196 - Growth Factors as Drugs for Neurological and Sensory Disorders

Ciba Foundation Symposium 196 - Growth Factors as Drugs for Neurological and Sensory Disorders

How to Cite

Tan, S. A. and Aebischer, P. (2007) The Problems of Delivering Neuroactive Molecules to the CNS, in Ciba Foundation Symposium 196 - Growth Factors as Drugs for Neurological and Sensory Disorders (eds G. R. Bock and J. A. Goode), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470514863.ch14

Author Information

  1. Gene Therapy Center and Division of Surgical Research, Lausanne University Medical School, CHU Vaudois, CH-1011 Lausanne, Switzerland

Publication History

  1. Published Online: 28 SEP 2007

ISBN Information

Print ISBN: 9780471957218

Online ISBN: 9780470514863

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Keywords:

  • neuroactive molecules;
  • transplanting cells;
  • delivering bioactive molecules;
  • blood-brain barrier;
  • central nervous system

Summary

At present, the aetiologies of many neurological and neurodegenerative diseases are unknown. However, emergence of a better understanding of these diseases, at both cellular and molecular levels, opens up the possibility of replacement therapies. The presence of the blood–brain barrier complicates the delivery of molecules to the central nervous system. Numerous attempts have been made to bypass this barrier either by delivering the drugs directly into the brain or by transplanting cells to produce the missing molecules in situ. This review explores several methods for delivering bioactive molecules into the CNS, including the use of permeabilizers, osmotic pumps, slow polymer release systems and transplantation of cells with or without the use of the encapsulation technology.