Development of Neurotrophic Factor Therapy for Alzheimer's Disease

  1. Gregory R. Bock Organizer and
  2. Jamie A. Goode
  1. Franz Hefti,
  2. Mark P. Armanini,
  3. Klaus D. Beck,
  4. Ingrid W. Caras,
  5. Karen S. Chen,
  6. Paul J. Godowski,
  7. Laurie J. Goodman,
  8. R. Glenn Hammonds,
  9. Melanie R. Mark,
  10. Paul Moran,
  11. Merry C. Nishimura,
  12. Heidi S. Phillips,
  13. Ai Shih,
  14. Janet Valverde and
  15. John W. Winslow

Published Online: 28 SEP 2007

DOI: 10.1002/9780470514863.ch5

Ciba Foundation Symposium 196 - Growth Factors as Drugs for Neurological and Sensory Disorders

Ciba Foundation Symposium 196 - Growth Factors as Drugs for Neurological and Sensory Disorders

How to Cite

Hefti, F., Armanini, M. P., Beck, K. D., Caras, I. W., Chen, K. S., Godowski, P. J., Goodman, L. J., Hammonds, R. G., Mark, M. R., Moran, P., Nishimura, M. C., Phillips, H. S., Shih, A., Valverde, J. and Winslow, J. W. (2007) Development of Neurotrophic Factor Therapy for Alzheimer's Disease, in Ciba Foundation Symposium 196 - Growth Factors as Drugs for Neurological and Sensory Disorders (eds G. R. Bock and J. A. Goode), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470514863.ch5

Author Information

  1. Departments of Neuroscience and Cell Genetics, Genentech Inc., 460 Point San Bruno Boulevard, South San Francisco, CA 94080, USA

  1. Merck, Sharp & Dohme Research Labs, Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK.

Publication History

  1. Published Online: 28 SEP 2007

ISBN Information

Print ISBN: 9780471957218

Online ISBN: 9780470514863

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Keywords:

  • neurotrophic factor therapy;
  • Alzheimer's disease;
  • nerve growth factor;
  • tyrosine kinase receptor genes;
  • hippocampal formation

Summary

Neurotrophic factor therapy of Alzheimer's disease aims at diminishing synapse and neuron loss, cardinal features of this disease that are probably highly relevant to the behavioural deficits it causes. Degenerative changes of ascending cholinergic neurons of the basal forebrain are prevented in animals by nerve growth factor (NGF). Recent investigations on mutant mice with deletions of the NGF gene confirm a close association between NGF, cholinergic function and cognitive behaviour, in support of the notion that NGF treatment may be beneficial in Alzheimer's disease. However, growth factors acting on neurons of the hippocampus and cortex will be necessary to protect the major populations of affected neurons. We have identified tyrosine kinase receptor genes expressed in the hippocampus and cortex using PCR approaches, and then searched for their ligands. This approach has identified the receptor REK7 and its ligand AL-1 and the receptor Rse and its ligand Gas-6 as growth factor/growth factor receptor systems expressed in cortex and hippocampus of the adult brain.