P2X Receptors: A Third Major Class of Ligand-Gated Ion Channels

  1. Derek J. Chadwick Organizer and
  2. Jamie A. Goode
  1. R. Alan North

Published Online: 28 SEP 2007

DOI: 10.1002/9780470514900.ch5

Ciba Foundation Symposium 198 - P2 Purinoceptors: Localization, Function and Transduction Mechanisms

Ciba Foundation Symposium 198 - P2 Purinoceptors: Localization, Function and Transduction Mechanisms

How to Cite

North, R. A. (2007) P2X Receptors: A Third Major Class of Ligand-Gated Ion Channels, in Ciba Foundation Symposium 198 - P2 Purinoceptors: Localization, Function and Transduction Mechanisms (eds D. J. Chadwick and J. A. Goode), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470514900.ch5

Author Information

  1. Glaxo Institute for Molecular Biology, 14 Chemin des Aulx, 1228 Plan-les-Ouates, CH-1211 Geneva, Switzerland

Publication History

  1. Published Online: 28 SEP 2007

ISBN Information

Print ISBN: 9780471961253

Online ISBN: 9780470514900

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Keywords:

  • P2X receptors;
  • P2X receptor function;
  • gaba receptors;
  • extracellular transmitters;
  • transmembrane domains

Summary

Three classes of ligand-gated ion channels are defined by their molecular architecture. The first embraces nicotinic, 5-HT3, glycine and GABA receptors. The second class contains the glutamate receptors—AMPA, kainate and NMDA types. The third class is the P2X receptors for ATP. Current knowledge of the structure of these channels is reviewed, and set beside what is known of their basic functional properties. The aim of this paper is to consider how our more complete understanding of the first two classes of channels might be helpful in forming a molecular picture of P2X receptor function.