Differentiation and Functions of T Cell Subsets
- Gregory R. Bock Organizer,
- Jamie A. Goode
Published Online: 28 SEP 2007
Copyright © 1997 John Wiley & Sons Ltd.
Ciba Foundation Symposium 204 - The Molecular Basis of Cellular Defence Mechanisms
How to Cite
Mosmann, T. R., Li, L., Hengartner, H., Kagi, D., Fu, W. and Sad, S. (2007) Differentiation and Functions of T Cell Subsets, in Ciba Foundation Symposium 204 - The Molecular Basis of Cellular Defence Mechanisms (eds G. R. Bock and J. A. Goode), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470515280.ch10
- Published Online: 28 SEP 2007
Print ISBN: 9780471965671
Online ISBN: 9780470515280
- T cell subsets;
- delayed type hypersensitivity;
- immune responses;
The Tc1 and Tc2 subsets of CD8+ T effector cells secrete different patterns of cytokines, but have similar functions, including perforin- and Fas-dependent cytotoxicity, and induction of delayed type hypersensitivity (DTH) reactions involving oedema and granulocytic infiltration. The characteristic cytokines of Tc1 (γ-interferon) and Tc2 (interleukins 4 and 5) are expressed in vivo during the DTH reaction. Tc1 cells that are deficient in cytokine synthesis also induce similar levels of DTH, supporting the lack of correlation between CD8+ T cell cytokine patterns and DTH. CD8+ T cells often produce lower cytokine levels than CD4 cells because the CD8 cells kill their antigen-presenting cells before full stimulation can occur. This effect can be counteracted by increasing the frequency of stimulation, or using perforin-deficient T cells. A multiparameter analysis of cytokine effects on CD8+ T cell differentiation has been initiated, on the basis of the principle that normal immune responses involve complex cytokine mixtures. All combinations of seven cytokines were tested. In some combinations, the combined effect could not have been predicted from individual cytokine functions. Conditions were identified in which each of interleukins 4, 10 and 12 could have opposite effects on CD8+ T cell differentiation.