T Cell Tolerance and Autoimmunity
- Gregory R. Bock Organizer and
- Jamie A. Goode
Published Online: 28 SEP 2007
Copyright © 1997 John Wiley & Sons Ltd.
Ciba Foundation Symposium 204 - The Molecular Basis of Cellular Defence Mechanisms
How to Cite
Miller, J. F. A. P., Heath, W. R., Allison, J., Morahan, G., Hoffmann, M., Kurts, C. and Kosaka, H. (2007) T Cell Tolerance and Autoimmunity, in Ciba Foundation Symposium 204 - The Molecular Basis of Cellular Defence Mechanisms (eds G. R. Bock and J. A. Goode), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470515280.ch11
- Published Online: 28 SEP 2007
Print ISBN: 9780471965671
Online ISBN: 9780470515280
- T cell tolerance;
- T cell receptor
Many T cells with auto-aggressive potential are deleted in the thymus. Although some of these escape to the general circulation, they do not usually damage organs such as the pancreas. To investigate the mechanisms preventing autoimmunity, we generated transgenic mice expressing known genes under the control of various promoters. We found that the occurrence of autoaggression depended on factors such as the precursor frequency of responding T cells, their state of activation, their accessibility to the autoantigen, the physicochemical properties of the autoantigen, the possibility of priming by environmental antigens which mimic the target antigen, and some inflammatory reaction in the target site.