Repair and Processing Events at DNA Ends

  1. Derek J. Chadwick Organizer and
  2. Gail Cardew Organizer
  1. Tomas Lindahl,
  2. Deborah E. Barnes,
  3. Arne Klungland,
  4. Victoria J. Mackenney and
  5. Primo Schär

Published Online: 28 SEP 2007

DOI: 10.1002/9780470515433.ch13

Ciba Foundation Symposium 211 - Telomeres and Telomerase

Ciba Foundation Symposium 211 - Telomeres and Telomerase

How to Cite

Lindahl, T., Barnes, D. E., Klungland, A., Mackenney, V. J. and Schär, P. (2007) Repair and Processing Events at DNA Ends, in Ciba Foundation Symposium 211 - Telomeres and Telomerase (eds D. J. Chadwick and G. Cardew), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470515433.ch13

Author Information

  1. Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK

Publication History

  1. Published Online: 28 SEP 2007

ISBN Information

Print ISBN: 9780471972785

Online ISBN: 9780470515433

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Keywords:

  • poly (ADP-ribose) formation;
  • DNA ligases;
  • excision-repair enzymes;
  • telomere-binding proteins;
  • replication factories

Summary

Cell nuclei contain several abundant enzymes that bind rapidly and avidly to exposed termini of DNA. The properties and physiological roles of such factors are described; they include poly (ADP-ribose) polymerase, DNA-dependent protein kinase, several DNA ligases and excision–repair enzymes. Telomeres normally seem shielded from these activities by telomere-binding proteins. If incomplete protection of telomeres occurred, the functions of the DNA end-specific enzymes would be relevant for processing of telomeres. This could include alternative pathways for telomerc propagation in telomerase-negative cells.