Chapter 16. Pharmacokinetics

  1. Robert J. Flanagan1,
  2. Andrew Taylor2,
  3. Ian D. Watson3,
  4. Robin Whelpton4

Published Online: 1 FEB 2008

DOI: 10.1002/9780470516294.ch16

Book Title

Fundamentals of Analytical Toxicology

Fundamentals of Analytical Toxicology

Additional Information

How to Cite

Flanagan, R. J., Taylor, A., Watson, I. D. and Whelpton, R. (2008) Pharmacokinetics, in Fundamentals of Analytical Toxicology, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470516294.ch16

Author Information

  1. 1

    Department of Clinical Biochemistry, King's College Hospital NHS Foundation Trust, London, UK

  2. 2

    Royal Surrey County Hospital, Guildford, Surrey, UK

  3. 3

    Department of Clinical Biochemistry, University Hospital Aintree, Liverpool, UK

  4. 4

    School of Biological and Chemical Sciences, Queen Mary, University of London, London, UK

Publication History

  1. Published Online: 1 FEB 2008
  2. Published Print: 25 JAN 2008

ISBN Information

Print ISBN: 9780470319345

Online ISBN: 9780470516294

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Keywords:

  • first-order elimination kinetics;
  • expected plasma concentrations;
  • controlled release (CR) or modified release (MR);
  • prolonged thiopental administration;
  • xenobiotic disposition and pharmacokinetics

Summary

This chapter contains sections titled:

  • Introduction

  • Fundamental concepts

  • Absorption and elimination

  • Drug accumulation

  • Sustained-release preparations

  • Non-linear pharmacokinetics

  • Multicompartment models

  • Model-independent pharmacokinetic parameters

  • Pharmacokinetics and the interpretation of results

  • Summary

  • References

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