Chapter 8. High-Performance Liquid Chromatography

  1. Robert J. Flanagan1,
  2. Andrew Taylor2,
  3. Ian D. Watson3,
  4. Robin Whelpton4

Published Online: 1 FEB 2008

DOI: 10.1002/9780470516294.ch8

Book Title

Fundamentals of Analytical Toxicology

Fundamentals of Analytical Toxicology

Additional Information

How to Cite

Flanagan, R. J., Taylor, A., Watson, I. D. and Whelpton, R. (2008) High-Performance Liquid Chromatography, in Fundamentals of Analytical Toxicology, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470516294.ch8

Author Information

  1. 1

    Department of Clinical Biochemistry, King's College Hospital NHS Foundation Trust, London, UK

  2. 2

    Royal Surrey County Hospital, Guildford, Surrey, UK

  3. 3

    Department of Clinical Biochemistry, University Hospital Aintree, Liverpool, UK

  4. 4

    School of Biological and Chemical Sciences, Queen Mary, University of London, London, UK

Publication History

  1. Published Online: 1 FEB 2008
  2. Published Print: 25 JAN 2008

ISBN Information

Print ISBN: 9780470319345

Online ISBN: 9780470516294

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CHAPTER TOOLS

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Keywords:

  • discrete excitation and emission wavelengths;
  • anticonvulsant vigibatrin and related compounds;
  • unsuitable physicochemical properties;
  • chiral ligand-exchange chromatography (CLEC);
  • base-deactivated bonded-phase silicas

Summary

This chapter contains sections titled:

  • Introduction

  • HPLC: general considerations

  • Detection in HPLC

  • Columns and column packings

  • Modes of HPLC

  • Chiral separations

  • Derivatives for HPLC

  • Use of HPLC in analytical toxicology

  • Summary

  • References

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