Chapter 1. Current in vitro Models to Study Drug-Induced Liver Injury

  1. Saura C. Sahu
  1. Julio C. Davila1,
  2. Jinghai J. Xu2,
  3. Keith A. Hoffmaster3,
  4. Peter J. O'Brien4,5 and
  5. Stephen C. Storm6

Published Online: 27 FEB 2008

DOI: 10.1002/9780470516751.ch1

Hepatotoxicity

Hepatotoxicity

How to Cite

Davila, J. C., Xu, J. J., Hoffmaster, K. A., O'Brien, P. J. and Storm, S. C. (2007) Current in vitro Models to Study Drug-Induced Liver Injury, in Hepatotoxicity (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470516751.ch1

Editor Information

  1. Division of Toxicology, Office of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

Author Information

  1. 1

    Pfizer Inc., PGRD, Saint Louis Laboratories, 700 Chesterfield Parkway North TA1, St Louis, MO 63017, USA

  2. 2

    Pfizer Inc., Research Training Center (RTC), 01/55564 Systems Biology, DTC 367, 620 Memorial Drive, Cambridge, MA 02139, USA

  3. 3

    Pfizer Inc., Research Training Center (RTC), 01/5R206 ADME Biology, DTC 308, 620 Memorial Drive, Cambridge, MA 02139, USA

  4. 4

    Pfizer Inc., Drug Safety Research and Development, Ramsgate Road, SSEU Europe 380/1.025, IPC 339, Sandwich, CT13 9NJ, UK

  5. 5

    Graduate Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON M5S 3M2, Canada

  6. 6

    Department of Pathology, University of Pittsburgh, 200 Lothrop Street, 450 South BST, Pittsburgh, PA 15261, USA

Publication History

  1. Published Online: 27 FEB 2008
  2. Published Print: 14 DEC 2007

ISBN Information

Print ISBN: 9780470057162

Online ISBN: 9780470516751

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Keywords:

  • hepatotoxicity and cardiovascular toxicity;
  • animal toxicity testing;
  • drug-induced liver injury (DILI);
  • animal model predictability and dose-dependency;
  • recommended therapeutic dose;
  • classic animal models;
  • patient-to-patient variability;
  • idiosyncratic hepatotoxicity;
  • genetic and non-genetic factors;
  • enzyme induction and inhibition

Summary

This chapter contains sections titled:

  • Introduction

  • In Vitro Models to Study DILI

  • Applications of in Vitro Models

  • Conclusions

  • References