Chapter 10. A Role of Cytochrome P450 in Quinone-Induced Hepatotoxicity

  1. Saura C. Sahu
  1. Yasuhiro Ishihara and
  2. Norio Shimamoto

Published Online: 27 FEB 2008

DOI: 10.1002/9780470516751.ch10



How to Cite

Ishihara, Y. and Shimamoto, N. (2007) A Role of Cytochrome P450 in Quinone-Induced Hepatotoxicity, in Hepatotoxicity (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470516751.ch10

Editor Information

  1. Division of Toxicology, Office of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

Author Information

  1. Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1, Shido, Sanuki, Kagawa 769-2193, Japan

Publication History

  1. Published Online: 27 FEB 2008
  2. Published Print: 14 DEC 2007

ISBN Information

Print ISBN: 9780470057162

Online ISBN: 9780470516751



  • animal and plant cells;
  • photosynthesis and respiratory chain;
  • antimalarial and antibacterial drugs;
  • quinone-based drugs;
  • quinones toxic mechanisms;
  • endoplasmic reticulum;
  • quinone-induced hepatotoxicity;
  • low-molecular-mass thiol compounds and protein thiols;
  • cellular redox homeostasis;
  • exogenous / endogenous oxidative stress


This chapter contains sections titled:

  • Introduction

  • Mechanism of Quinone-Induced Hepatotoxicity

  • A Role of Cytochrome P450 in Quinone-Induced Hepatotoxicity

  • Concluding Remarks

  • Acknowledgements

  • Abbreviations

  • References