Chapter 12. Role of the Kupffer Cell in Hepatotoxicity and Hepatocarcinogenesis

  1. Saura C. Sahu
  1. James E. Klaunig,
  2. Stacy M. Corthals,
  3. Lisa M. Kamendulis and
  4. Binu K. Philip

Published Online: 27 FEB 2008

DOI: 10.1002/9780470516751.ch12



How to Cite

Klaunig, J. E., Corthals, S. M., Kamendulis, L. M. and Philip, B. K. (2007) Role of the Kupffer Cell in Hepatotoxicity and Hepatocarcinogenesis, in Hepatotoxicity (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470516751.ch12

Editor Information

  1. Division of Toxicology, Office of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

Author Information

  1. Center for Environmental Health, Department of Pharmacology and Toxicology, Indiana School of Medicine, 541 Clinical Drive, Indianapolis, IN 46202, USA

Publication History

  1. Published Online: 27 FEB 2008
  2. Published Print: 14 DEC 2007

ISBN Information

Print ISBN: 9780470057162

Online ISBN: 9780470516751



  • parenchymal cells;
  • mononuclear phagocyte system;
  • sinusoidal nonparenchymal cell types;
  • centrilobular regions;
  • sinusoidal endothelial cells;
  • endogenous and exogenous compounds;
  • endocytic mechanisms;
  • phagocytic vesicles;
  • endogenous peroxidase patterns;
  • immune and inflammatory responses


This chapter contains sections titled:

  • Introduction

  • Kupffer Cell Function

  • Role of the Kupffer cell in Hepatotoxicity

  • Role of the Kupffer cell in Liver Carcinogenesis

  • Summary

  • References