Chapter 13. Sinusoidal Cells in Liver Injury and Repair

  1. Saura C. Sahu
  1. Carol R. Gardner and
  2. Debra L. Laskin

Published Online: 27 FEB 2008

DOI: 10.1002/9780470516751.ch13



How to Cite

Gardner, C. R. and Laskin, D. L. (2007) Sinusoidal Cells in Liver Injury and Repair, in Hepatotoxicity (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470516751.ch13

Editor Information

  1. Division of Toxicology, Office of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

Author Information

  1. Department of Pharmacology and Toxicology, Rutgers University, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA

Publication History

  1. Published Online: 27 FEB 2008
  2. Published Print: 14 DEC 2007

ISBN Information

Print ISBN: 9780470057162

Online ISBN: 9780470516751



  • phagocytic leukocytes;
  • hepatic sinusoidal cells;
  • inflammatory cytotoxic cytokines;
  • hepatocyte protein and nucleic acid biosynthesis;
  • cytochrome P450-mediated metabolism;
  • homeostatic conditions;
  • normal liver architecture;
  • endothelial cells and stellate cells;
  • tumor necrosis factor-α (TNFα);
  • hepatocyte growth factor


This chapter contains sections titled:

  • Introduction

  • Hepatic Nonparenchymal Cells

  • Acetaminophen Hepatotoxicity

  • Carbon Tetrachloride Hepatotoxicity

  • Conclusions

  • Acknowledgements

  • References