Chapter 17. Application of Toxicogenomics in Predicting Hepatotoxicity – Potentials and Challenges

  1. Saura C. Sahu
  1. Wen Lin,
  2. Guoxiang Shen,
  3. Tin Oo Khor and
  4. Ah-Ng Tony Kong

Published Online: 27 FEB 2008

DOI: 10.1002/9780470516751.ch17



How to Cite

Lin, W., Shen, G., Khor, T. O. and Tony Kong, A.-N. (2007) Application of Toxicogenomics in Predicting Hepatotoxicity – Potentials and Challenges, in Hepatotoxicity (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470516751.ch17

Editor Information

  1. Division of Toxicology, Office of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

Author Information

  1. Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA

Publication History

  1. Published Online: 27 FEB 2008
  2. Published Print: 14 DEC 2007

ISBN Information

Print ISBN: 9780470057162

Online ISBN: 9780470516751



  • Drug-induced hepatotoxicity;
  • acute and chronic liver diseases;
  • drug-induced idiosyncratic hepatotoxicity;
  • drug withdrawal post-marketing;
  • serum toxicity biomarkers level;
  • gene expression profiles;
  • primary upstream events;
  • microarray-based toxicogenomics;
  • potential liver toxicity;
  • genome-scale DNA sequences


This chapter contains sections titled:

  • Introduction

  • Methodology

  • Data Analysis

  • Applications

  • Summary of Potentials and Pitfalls

  • Abbreviations

  • Acknowledgements

  • References