Chapter 19. Use of DNA Arrays in Understanding Hepatic Test Systems

  1. Saura C. Sahu
  1. Angela J. Harris1 and
  2. Daniel A. Casciano2,3

Published Online: 27 FEB 2008

DOI: 10.1002/9780470516751.ch19

Hepatotoxicity

Hepatotoxicity

How to Cite

Harris, A. J. and Casciano, D. A. (2007) Use of DNA Arrays in Understanding Hepatic Test Systems, in Hepatotoxicity (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470516751.ch19

Editor Information

  1. Division of Toxicology, Office of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

Author Information

  1. 1

    Center for Toxicology and Environmental Health, LLC, 615 W. Markham, Little Rock, AR 72201, USA

  2. 2

    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA

  3. 3

    Dan Casciano and Associates, 47 Marcella Drive, Little Rock, Little Rock, AR 72223, USA

Publication History

  1. Published Online: 27 FEB 2008
  2. Published Print: 14 DEC 2007

ISBN Information

Print ISBN: 9780470057162

Online ISBN: 9780470516751

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Keywords:

  • basal gene expression;
  • genetically homogenous rodents;
  • toxicological testing;
  • hepatic testing systems;
  • genes and multiple investigators;
  • hepatic test systems;
  • cultured hepatocytes;
  • functional acinar structure;
  • multicellular environment;
  • liver-specific metabolic functions

Summary

This chapter contains sections titled:

  • Introduction

  • Commonly Used Hepatic Systems in Toxicological Testing

  • Basal Gene Expression in Whole Liver and In Vitro

  • Comparisons of in vivo and in vitro

  • Effects of Culture Conditions

  • Summary

  • References