Chapter 2. Utilization of an in vitro Hepatotoxicity Test in the Early Stage of Drug Discovery

  1. Saura C. Sahu
  1. Ikuo Horii,
  2. Hiroshi Yamada,
  3. Rie Kikkawa,
  4. Toshinori Yamamoto,
  5. Tamio Fukushima and
  6. Kaori Tomizawa

Published Online: 27 FEB 2008

DOI: 10.1002/9780470516751.ch2



How to Cite

Horii, I., Yamada, H., Kikkawa, R., Yamamoto, T., Fukushima, T. and Tomizawa, K. (2007) Utilization of an in vitro Hepatotoxicity Test in the Early Stage of Drug Discovery, in Hepatotoxicity (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470516751.ch2

Editor Information

  1. Division of Toxicology, Office of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

Author Information

  1. Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Central Research Laboratories, SS-Nagoya, Pfizer Japan Inc., 5–2 Taketoyo, Aichi 470–2393, Japan

Publication History

  1. Published Online: 27 FEB 2008
  2. Published Print: 14 DEC 2007

ISBN Information

Print ISBN: 9780470057162

Online ISBN: 9780470516751



  • molecular targeting;
  • drug discovery research introduction;
  • toxicological strategies series;
  • High-Throughput Toxicology (HTP-Tox);
  • toxicopanomics technologies;
  • predictive toxicology and mechanism-based risk assessment;
  • toxicological mechanisms;
  • hepatotoxicity evaluation systems;
  • oxidative stress-related proteins expression;
  • metabolic enzyme-related genes expression and inflammation-related genes expression


This chapter contains sections titled:

  • General Introduction

  • Introduction of in vitro Screening Tests

  • Correlations between in vitro Systems and in vivo Systems

  • Application of Toxicopanomics Technologies to in vitro Safety Evaluation Systems

  • Introduction of Evaluation Systems Using in vitro Hepatotoxicity Tests in the Early Phase of Drug Discovery

  • Future Prospects

  • References