Chapter 22. Human and Animal-Based Differences in Hepatic Xenobiotic Metabolism and Toxicity

  1. Saura C. Sahu
  1. Peter J. O'Brien1,2,
  2. Katie Chan2 and
  3. Raymond Poon3

Published Online: 27 FEB 2008

DOI: 10.1002/9780470516751.ch22



How to Cite

O'Brien, P. J., Chan, K. and Poon, R. (2008) Human and Animal-Based Differences in Hepatic Xenobiotic Metabolism and Toxicity, in Hepatotoxicity (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470516751.ch22

Editor Information

  1. Division of Toxicology, Office of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

Author Information

  1. 1

    Pfizer Inc., Drug Safety Research and Development, Ramsgate Road, SSEU Europe 380/1.025, IPC 339, Sandwich, CT13 9NJ, UK

  2. 2

    Graduate Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, ON M5S 3M2, Canada

  3. 3

    Environmental and Occupational Toxicology Division, Health Canada, Ottawa, ON K1A 0L2, Canada

Publication History

  1. Published Online: 27 FEB 2008
  2. Published Print: 14 DEC 2007

ISBN Information

Print ISBN: 9780470057162

Online ISBN: 9780470516751



  • immune thrombocytopenic purpura;
  • irritable bowel syndrome;
  • drug-induced adverse reaction diseases;
  • rodent and pig hepatic enzymes;
  • pharmacokinetics and pharmacodynamics;
  • life-threatening diseases;
  • drug development and clinical evaluation;
  • higher body fat percentage and lower average body weight;
  • pharmacokinetic parameters;
  • amobarbital anesthetized female rats


This chapter contains sections titled:

  • Introduction

  • Gender-Specific Animal Hepatic Enzymes

  • Human Liver

  • Gender-Based Hepatotoxicity and Regulatory Toxicology

  • Conclusions

  • References