Chapter 24. The Potent Rat Hepatocarcinogen Methapyrilene: An Hypothesis Regarding its Hepatotoxicology

  1. Saura C. Sahu
  1. Daniel A. Casciano1,2

Published Online: 27 FEB 2008

DOI: 10.1002/9780470516751.ch24



How to Cite

Casciano, D. A. (2007) The Potent Rat Hepatocarcinogen Methapyrilene: An Hypothesis Regarding its Hepatotoxicology, in Hepatotoxicity (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470516751.ch24

Editor Information

  1. Division of Toxicology, Office of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

Author Information

  1. 1

    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA

  2. 2

    Dan Casciano and Associates, 47 Marcella Drive, Little Rock, Little Rock, AR 72223, USA

Publication History

  1. Published Online: 27 FEB 2008
  2. Published Print: 14 DEC 2007

ISBN Information

Print ISBN: 9780470057162

Online ISBN: 9780470516751



  • hepatocellular carcinomas and cholangiocarcinomas;
  • nitrite and amine drugs administration;
  • chemical-induced cancer;
  • enzyme-altered foci formation;
  • genotoxic carcinogen;
  • enzyme-altered foci;
  • mixed-function oxidase activities;
  • mitochondrial and microsomal membranes;
  • dose-dependent increase;
  • hepatocellular replication and mitochondrial protein alterations


This chapter contains sections titled:

  • Introduction

  • Follow-Up Carcinogenicity Studies

  • Genotoxicity Studies

  • Autophagy and Endocytosis

  • Methapyrilene and Autophagy

  • Summary

  • References