Chapter 26. Physiologically Based Pharmokinetic Modeling and Risk Assessment of Hepatotoxicants

  1. Saura C. Sahu
  1. Kannan Krishnan

Published Online: 27 FEB 2008

DOI: 10.1002/9780470516751.ch26



How to Cite

Krishnan, K. (2007) Physiologically Based Pharmokinetic Modeling and Risk Assessment of Hepatotoxicants, in Hepatotoxicity (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470516751.ch26

Editor Information

  1. Division of Toxicology, Office of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

Author Information

  1. Département de Santé Environmental/Santé an Travail, Université de Montréal, 2375 Cote Ste Catherine, Bureau 4105, Montréal, QC H3T 1A8, Canada

Publication History

  1. Published Online: 27 FEB 2008
  2. Published Print: 14 DEC 2007

ISBN Information

Print ISBN: 9780470057162

Online ISBN: 9780470516751



  • health risk assessment process;
  • physiologically based pharmacokinetic (PBPK) models;
  • metabolism and excretion;
  • perfusion and tissue-partitioning;
  • high-molecular-weight compounds;
  • rate-limiting process;
  • mass-balance differential equation;
  • organ-specific clearance and concentration;
  • inhaled volatile organic chemical;
  • animal-alternative approach


This chapter contains sections titled:

  • Introduction

  • Development of PBPK Models

  • Estimating the Parameters of PBPK Models

  • PBPK Model-Based Extrapolations in Health Risk Assessment

  • Examples of the Application of the PBPK Model in the Risk Assessment of Hepatotoxicants

  • Physiological Modeling and Risk Assessment of Hepatotoxicant Mixtures

  • Concluding Remarks

  • References