Chapter 5. Hepatocytes as a Model for Screening Food-Related Hepatotoxins and Studying Mechanisms of their Toxicity

  1. Saura C. Sahu
  1. Saura C. Sahu

Published Online: 27 FEB 2008

DOI: 10.1002/9780470516751.ch5

Hepatotoxicity

Hepatotoxicity

How to Cite

Sahu, S. C. (2007) Hepatocytes as a Model for Screening Food-Related Hepatotoxins and Studying Mechanisms of their Toxicity, in Hepatotoxicity (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470516751.ch5

Editor Information

  1. Division of Toxicology, Office of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

Author Information

  1. Division of Toxicology, Office of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

Publication History

  1. Published Online: 27 FEB 2008
  2. Published Print: 14 DEC 2007

ISBN Information

Print ISBN: 9780470057162

Online ISBN: 9780470516751

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Keywords:

  • xenobiotic metabolism;
  • food-related toxins;
  • food-borne microbial pathogens and food-related products;
  • toxicological risk assessment;
  • reproducible experimental conditions;
  • toxicity and structure–activity relationships study mechanisms;
  • cellular and molecular level;
  • reduced viability and metabolizing enzyme activities;
  • Cryopreserved primary human hepatocytes;
  • High inter-individual variability

Summary

This chapter contains sections titled:

  • Introduction

  • Hepatocyte Cultures

  • Limitations of the Hepatocyte Culture Model

  • Endpoints of Hepatotoxicity

  • Application of Hepatocyte Cultures

  • Conclusions

  • Acknowledgments

  • References