Chapter 11. Liquid Chromatography/Mass Spectrometry

  1. J. Throck Watson Professor1 and
  2. O. David Sparkman Adjunct Professor2

Published Online: 20 JUN 2008

DOI: 10.1002/9780470516898.ch11

Introduction to Mass Spectrometry: Instrumentation, Applications and Strategies for Data Interpretation, Fourth Edition

Introduction to Mass Spectrometry: Instrumentation, Applications and Strategies for Data Interpretation, Fourth Edition

How to Cite

Watson, J. T. and Sparkman, O. D. (2007) Liquid Chromatography/Mass Spectrometry, in Introduction to Mass Spectrometry: Instrumentation, Applications and Strategies for Data Interpretation, Fourth Edition, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470516898.ch11

Author Information

  1. 1

    Michigan State University, East Lansing, Michigan, USA

  2. 2

    College of the Pacific, University of the Pacific, Stockton, California, USA

Publication History

  1. Published Online: 20 JUN 2008
  2. Published Print: 5 OCT 2007

ISBN Information

Print ISBN: 9780470516348

Online ISBN: 9780470516898

SEARCH

Keywords:

  • liquid chromatography/mass spectrometry (LC/MS);
  • high-performance liquid chromatograph (HPLC);
  • atmospheric pressure ionization (API);
  • LC/MS thermospray approach;
  • atmospheric pressure photoionization (APPI);
  • selected reaction monitoring (SRM) and MS/MS system;
  • APCI chemical ionization (CI) efficiency;
  • electrospray ionization signal (ESI) and APCI signal;
  • high-throughput analytical solid-phase extraction scheme

Summary

This chapter contains sections titled:

  • Introduction

  • Historical Milestones in the Development of the Interface

  • Currently Viable Versions of the Interface

  • Special Operation of LC under MS Conditions

  • Applications

  • References