Chapter 10. Discovery of MK-0457 (VX-680)
- Rongshi Li,
- Jeffrey A. Stafford
Published Online: 28 SEP 2009
DOI: 10.1002/9780470524961.ch10
Copyright © 2009 John Wiley & Sons, Inc.
Book Title
Kinase Inhibitor Drugs
Additional Information
How to Cite
Golec, J. M. C. (2009) Discovery of MK-0457 (VX-680), in Kinase Inhibitor Drugs (eds R. Li and J. A. Stafford), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470524961.ch10
Editor Information
Takeda San Diego, Inc., San Diego, CA 92121, USA
Publication History
- Published Online: 28 SEP 2009
- Published Print: 2 OCT 2009
ISBN Information
Print ISBN: 9780470278291
Online ISBN: 9780470524961
- Summary
- Chapter
- References
Keywords:
- cell cycle kinase inhibitors - Aurora kinase and PLK inhibitors;
- MK-0457 (VX-680) discovery;
- insights into mechanism and structure–activity relationships
Summary
This chapter contains sections titled:
Introduction
Early Medicinal Chemistry
First Crystal Structures
First in vivo Experiments
The Discovery of MK-0457 (VX-680)
Insights into Mechanism and Structure-Activity Relationships
MK-0457 (VX-680) and ABL
Other Aurora Inhibitors
Summary
Acknowledgment
References