Chapter 14. Discovery of GSK461364: A Polo-Like Kinase 1 Inhibitor for the Treatment of Cancer

  1. Rongshi Li and
  2. Jeffrey A. Stafford
  1. Kevin W. Kuntz and
  2. Kyle A. Emmitte

Published Online: 28 SEP 2009

DOI: 10.1002/9780470524961.ch14

Kinase Inhibitor Drugs

Kinase Inhibitor Drugs

How to Cite

Kuntz, K. W. and Emmitte, K. A. (2009) Discovery of GSK461364: A Polo-Like Kinase 1 Inhibitor for the Treatment of Cancer, in Kinase Inhibitor Drugs (eds R. Li and J. A. Stafford), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470524961.ch14

Editor Information

  1. Takeda San Diego, Inc., San Diego, CA 92121, USA

Author Information

  1. GlaxoSmithKline R&D, Research Triangle Park, NC 27709, USA

Publication History

  1. Published Online: 28 SEP 2009
  2. Published Print: 2 OCT 2009

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470278291

Online ISBN: 9780470524961

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Keywords:

  • GSK461364 discovery;
  • Plk1 structure–activity relationships;
  • substitution on chiral benzyl ether

Summary

This chapter contains sections titled:

  • Introduction

  • Background

  • Plk1 STRUCTURE-Activity Relationships

  • Summary

  • References