Chapter 17. Approaches to Kinase Homology Modeling: Successes and Considerations for the Structural Kinome

  1. Rongshi Li and
  2. Jeffrey A. Stafford
  1. Victoria A. Feher and
  2. J. David Lawson

Published Online: 28 SEP 2009

DOI: 10.1002/9780470524961.ch17

Kinase Inhibitor Drugs

Kinase Inhibitor Drugs

How to Cite

Feher, V. A. and Lawson, J. D. (2009) Approaches to Kinase Homology Modeling: Successes and Considerations for the Structural Kinome, in Kinase Inhibitor Drugs (eds R. Li and J. A. Stafford), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470524961.ch17

Editor Information

  1. Takeda San Diego, Inc., San Diego, CA 92121, USA

Author Information

  1. Department of Computational Sciences, Takeda San Diego, Inc., San Diego, CA 92121, USA

Publication History

  1. Published Online: 28 SEP 2009
  2. Published Print: 2 OCT 2009

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470278291

Online ISBN: 9780470524961

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Keywords:

  • kinase homology modeling approaches - successes and considerations for structural kinome;
  • kinase homology modeling utilizing traditional modeling methods;
  • accommodating active versus inactive kinase conformations

Summary

This chapter contains sections titled:

  • Introduction

  • Examples of Kinase Homology Modeling Utilizing Traditional Modeling Methods

  • Advantages of Subfamily Homology

  • Accommodating Active Versus Inactive Kinase Conformations

  • A Chemogenomic Approach to Kinase Homology Modeling

  • Considerations for “Twilight Zone” Kinase Homologs

  • Summary

  • References