Chapter 19. Protein Kinase Structural Biology: Methods and Strategies for Targeted Drug Discovery

  1. Rongshi Li and
  2. Jeffrey A. Stafford
  1. Clifford D. Mol,
  2. Kengo Okada and
  3. David J. Hosfield

Published Online: 28 SEP 2009

DOI: 10.1002/9780470524961.ch19

Kinase Inhibitor Drugs

Kinase Inhibitor Drugs

How to Cite

Mol, C. D., Okada, K. and Hosfield, D. J. (2009) Protein Kinase Structural Biology: Methods and Strategies for Targeted Drug Discovery, in Kinase Inhibitor Drugs (eds R. Li and J. A. Stafford), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470524961.ch19

Editor Information

  1. Takeda San Diego, Inc., San Diego, CA 92121, USA

Author Information

  1. Department of Structural Biology, Takeda San Diego, Inc., San Diego, CA 92121, USA

Publication History

  1. Published Online: 28 SEP 2009
  2. Published Print: 2 OCT 2009

Book Series:

  1. Wiley Series in Drug Discovery and Development

Book Series Editors:

  1. Binghe Wang

ISBN Information

Print ISBN: 9780470278291

Online ISBN: 9780470524961

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Keywords:

  • protein kinase structural biology - targeted drug discovery strategies;
  • kinase inhibition and targeting allosteric sites;
  • kinase inhibition by targeting active conformations

Summary

This chapter contains sections titled:

  • Introduction

  • Methods for Kinase Structural Biology

  • Kinase Architecture

  • Kinase Inhibition by Targeting Active Conformations

  • Kinase Inhibition by Targeting Inactive Conformations

  • Kinase Inhibition by Targeting Allosteric Sites

  • Summary and Perspectives

  • References