Chapter 1. Theoretical Modeling of Radiation-Induced DNA Damage

  1. Marc M. Greenberg
  1. Anil Kumar and
  2. Michael D. Sevilla

Published Online: 28 SEP 2009

DOI: 10.1002/9780470526279.ch1

Radical and Radical Ion Reactivity in Nucleic Acid Chemistry

Radical and Radical Ion Reactivity in Nucleic Acid Chemistry

How to Cite

Kumar, A. and Sevilla, M. D. (2009) Theoretical Modeling of Radiation-Induced DNA Damage, in Radical and Radical Ion Reactivity in Nucleic Acid Chemistry (ed M. M. Greenberg), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470526279.ch1

Editor Information

  1. Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA

Author Information

  1. Department of Chemistry, Oakland University, Rochester, MI 48309, USA

Publication History

  1. Published Online: 28 SEP 2009
  2. Published Print: 18 SEP 2009

Book Series:

  1. Wiley Series of Reactive Intermediates in Chemistry and Biology

Book Series Editors:

  1. Steven E. Rokita

ISBN Information

Print ISBN: 9780470255582

Online ISBN: 9780470526279

SEARCH

Keywords:

  • theoretical modeling of radiation-induced DNA damage;
  • direct effect of ionizing radiation in radical ion formation;
  • hole delocalization in adenine stacks

Summary

This chapter contains sections titled:

  • Introduction

  • Direct Effect of Ionizing Radiation in Radical Ion Formation

  • Formation of Sugar Radicals Via Photoexcitation of One-Electron Oxidized Nucleosides and Oligomers

  • Radicals and Tautomers of Deprotonated Guanine Radical Cation (G⋅+)

  • Nature of Hole Delocalization in Adenine Stacks: The Dimer Radical Cation (A2)⋅+

  • Conclusions

  • Acknowledgments

  • References