Chapter 13. DNA Damage Due to Diradical-Generating Cyclizations

  1. Marc M. Greenberg
  1. Sean M. Kerwin

Published Online: 28 SEP 2009

DOI: 10.1002/9780470526279.ch13

Radical and Radical Ion Reactivity in Nucleic Acid Chemistry

Radical and Radical Ion Reactivity in Nucleic Acid Chemistry

How to Cite

Kerwin, S. M. (2009) DNA Damage Due to Diradical-Generating Cyclizations, in Radical and Radical Ion Reactivity in Nucleic Acid Chemistry (ed M. M. Greenberg), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470526279.ch13

Editor Information

  1. Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA

Author Information

  1. Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA

Publication History

  1. Published Online: 28 SEP 2009
  2. Published Print: 18 SEP 2009

Book Series:

  1. Wiley Series of Reactive Intermediates in Chemistry and Biology

Book Series Editors:

  1. Steven E. Rokita

ISBN Information

Print ISBN: 9780470255582

Online ISBN: 9780470526279

SEARCH

Keywords:

  • DNA damage due to diradical-generating cyclizations;
  • enyne cumulene cyclization of NCS-chromophore;
  • Myers–Saito cyclization of enyne allenes

Summary

This chapter contains sections titled:

  • Introduction

  • Diradical-Generating Cyclizations of Enediyne Natural Products

  • DNA Cleavage Chemistry of Enediyne Natural Products

  • DNA Adducts and Cross-Links with Enediyne Natural Products

  • Designed DNA Cleavage Agents Based on Other Diradical-Generating Cyclizations

  • Conclusions

  • Acknowledgments

  • References