Chapter 3. Chemical Reactions of the Radical Cations of Nucleobases in Isolated and Cellular DNA. Formation of Single-Base Lesions

  1. Marc M. Greenberg
  1. Jean Cadet1,2,
  2. Thierry Douki1,
  3. Didier Gasparutto1,
  4. Jean-Luc Ravanat1 and
  5. J. Richard Wagner2

Published Online: 28 SEP 2009

DOI: 10.1002/9780470526279.ch3

Radical and Radical Ion Reactivity in Nucleic Acid Chemistry

Radical and Radical Ion Reactivity in Nucleic Acid Chemistry

How to Cite

Cadet, J., Douki, T., Gasparutto, D., Ravanat, J.-L. and Wagner, J. R. (2009) Chemical Reactions of the Radical Cations of Nucleobases in Isolated and Cellular DNA. Formation of Single-Base Lesions, in Radical and Radical Ion Reactivity in Nucleic Acid Chemistry (ed M. M. Greenberg), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470526279.ch3

Editor Information

  1. Department of Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA

Author Information

  1. 1

    Laboratoire Lésions des Acides Nucléiques, SCIB-UMR-E no. 3 (CEA/UJF), Institut Nanosciences et Cryogénie, CEA/Grenoble, F-38054 Grenoble Cedex 9, France

  2. 2

    Département de Médecine Nucléaire et Radiobiologie, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Québec, Canada J1H 5N4

Publication History

  1. Published Online: 28 SEP 2009
  2. Published Print: 18 SEP 2009

Book Series:

  1. Wiley Series of Reactive Intermediates in Chemistry and Biology

Book Series Editors:

  1. Steven E. Rokita

ISBN Information

Print ISBN: 9780470255582

Online ISBN: 9780470526279

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Keywords:

  • chemical reactions of radical cations of nucleobases;
  • one-electron oxidation reactions of normal pyrimidine;
  • one-electron oxidation pathways and five main DNA bases

Summary

This chapter contains sections titled:

  • Introduction

  • One-Electron Oxidation Reactions of Normal Pyrimidine and Purine Bases in Model Compounds and Isolated DNA

  • One-Electron Oxidation Reactions of Oxidized Pyrimidine and Purine DNA Bases

  • One-Electron Oxidation Reactions of Cellular DNA

  • Conclusions and Perspectives

  • References