Unit

Overview of Liquid Handling Instrumentation for High-Throughput Screening Applications

  1. Stewart Rudnicki,
  2. Sean Johnston

Published Online: 1 DEC 2009

DOI: 10.1002/9780470559277.ch090151

Current Protocols in Chemical Biology

Current Protocols in Chemical Biology

How to Cite

Rudnicki, S. and Johnston, S. 2009. Overview of Liquid Handling Instrumentation for High-Throughput Screening Applications. Current Protocols in Chemical Biology. 1:43–54.

Author Information

  1. ICCB-Longwood Screening Facility, Harvard Medical School, Boston, Massachusetts

Publication History

  1. Published Online: 1 DEC 2009

Abstract

Liquid handling in the laboratory has unique challenges specific to the types of research being performed. The devices employed for purposes of performing liquid handling can be broken down into three general categories: bulk reagent dispensers, transfer devices, and plate washers. An overview of these types of liquid handlers, as well as common features and relevance to high-throughput applications, are discussed in this article. Important topics such as sterility, ease of use, cost, and instrument design advantages and disadvantages are also covered. Curr. Protoc. Chem Biol. 1:43-54. © 2009 by John Wiley & Sons, Inc.

Keywords:

  • liquid handling;
  • high throughput screening (HTS);
  • laboratory automation;
  • plate filler;
  • plate washer