19. Single-Gene and Whole-Genome Duplications and the Evolution of Protein–Protein Interaction Networks

  1. Gustavo Caetano-Anollés
  1. Grigoris Amoutzias1 and
  2. Yves Van de Peer2

Published Online: 12 JUL 2010

DOI: 10.1002/9780470570418.ch19

Evolutionary Genomics and Systems Biology

Evolutionary Genomics and Systems Biology

How to Cite

Amoutzias, G. and Van de Peer, Y. (2010) Single-Gene and Whole-Genome Duplications and the Evolution of Protein–Protein Interaction Networks, in Evolutionary Genomics and Systems Biology (ed G. Caetano-Anollés), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470570418.ch19

Editor Information

  1. Bioinformatics Laboratory, Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Author Information

  1. 1

    VIB Department of Plant Systems Biology, Ghent University, Belgium, Brussels

  2. 2

    VIB Department of Plant Systems Biology, Ghent University, Belgium

Publication History

  1. Published Online: 12 JUL 2010
  2. Published Print: 1 MAR 2010

ISBN Information

Print ISBN: 9780470195147

Online ISBN: 9780470570418

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Keywords:

  • single-gene and whole-genome duplications and protein–protein interaction network evolution;
  • gene duplications, point mutations, and domain rearrangements - shaping regulatory and protein interaction networks;
  • dimerization, formation of functional protein complex of two subunits

Summary

This chapter contains sections titled:

  • Introduction

  • Evolution of PINs

  • Single-Gene Duplications

  • Whole-Genome Duplications

  • Diploidization Phase

  • Dosage Balance Hypothesis

  • Types of Interactions

  • WGDs, Transient Interactions, and Organismal Complexity

  • Studies on PPIs of Ohnologues

  • Concerns About the Methods of Analysis and the Quality of the Data

  • The Importance of Medium-Scale Studies: the Case of Dimerization

  • Evolution of Dimerization Networks

  • Conclusions

  • Acknowledgment

  • References