Standard Article

Single-Dose (Acute) and Pilot (DRF) Toxicity Testing in Drug Safety Evaluation

Drug Safety Evaluation, 2nd Edition

Published Online: 15 MAR 2010

DOI: 10.1002/9780470571224.pse132

Pharmaceutical Sciences Encyclopedia

Pharmaceutical Sciences Encyclopedia

How to Cite

2010. Single-Dose (Acute) and Pilot (DRF) Toxicity Testing in Drug Safety Evaluation. Pharmaceutical Sciences Encyclopedia. 6:1–49.

Publication History

  1. Published Online: 15 MAR 2010

Abstract

Acute toxicity testing is the evaluation of the toxic syndrome produced by a single or a few doses over the course of a day, such as two or three times per day of a drug. It is used as a part of occupational health environmental impact assessments and batch release testing. This article focuses on the various types of acute toxicity study designs, their utility in pharmaceutical product testing, their limitation, and the resultant sample data.

Keywords:

  • acute toxicity testing;
  • dose range finders (DRFs);
  • dose probe studies;
  • median lethal dose (LD50) test;
  • minimum lethal dosage (MLD);
  • toxicity testing