Plasmid DNA and Messenger RNA for Therapy
Published Online: 15 MAR 2010
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Pharmaceutical Sciences Encyclopedia
How to Cite
Pascolo, S. 2010. Plasmid DNA and Messenger RNA for Therapy. Pharmaceutical Sciences Encyclopedia. 31:1–42.
- Published Online: 15 MAR 2010
Recent studies performed in animal models and humans show that injection of pDNA or mRNA is safe and can elicit the expected results. Because pDNA and stabilized mRNA have the natural capacity to activate the immune system through the triggering of TLR, pDNA- and mRNA-based therapeutic utilizations are mostly tested in the field of vaccination. This article focuses on therapeutic applications of pDNA- and mRNA-based approaches.
- plasmid DNA (pDNA);
- messenger RNA (mRNA);
- gene therapy