Clearance of Nanoparticles During Circulation
Nanoparticulate Drug Delivery Systems: Strategies, Technologies, and Applications
Published Online: 19 JUN 2013
Copyright © 2010 John Wiley & Sons, Inc. All rights reserved.
Pharmaceutical Sciences Encyclopedia
How to Cite
Lee, S.-Y. and Cheng, J.-X. 2013. Clearance of Nanoparticles During Circulation. Pharmaceutical Sciences Encyclopedia. 1–32.
- Published Online: 19 JUN 2013
Nanoparticles are regarded as efficient drug delivery systems because they possess strong drug loading capacity and can pass through anatomical barriers easily. Specifically, the discovery of tumor-specific ligands allowed more efficient delivery of nanoparticles to cancer cells. The blood-circulation time is a key factor in determining the targeting efficiency of nanoparticles, and the rate of biological clearance is classified into three categories: (i) disintegration of nanoparticles by protein adsorption, (ii) opsonization-mediated nanoparticle removal by immune cells, and (iii) filtration by organs with fenestrated vasculature. This chapter discusses these three categories as well as strategies to modify nanoparticles to extend the circulation time of nanoparticles in the blood stream.
- cancer therapy;
- drug carrier;
- tumor targeting;
- drug delivery;