Chapter 2. Endoplasmic Reticulum Stress and Oxidative Stress: Mechanisms and Link to Disease

  1. Marina Ramirez-Alvarado3,
  2. Jeffery W. Kelly4 and
  3. Christopher M. Dobson5
  1. Jyoti D. Malhotra1 and
  2. Randal J. Kaufman2

Published Online: 2 JUL 2010

DOI: 10.1002/9780470572702.ch2

Protein Misfolding Diseases: Current and Emerging Principles and Therapies

Protein Misfolding Diseases: Current and Emerging Principles and Therapies

How to Cite

Malhotra, J. D. and Kaufman, R. J. (2010) Endoplasmic Reticulum Stress and Oxidative Stress: Mechanisms and Link to Disease, in Protein Misfolding Diseases: Current and Emerging Principles and Therapies (eds M. Ramirez-Alvarado, J. W. Kelly and C. M. Dobson), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470572702.ch2

Editor Information

  1. 3

    Mayo Clinic College of Medicine, USA

  2. 4

    The Scripps Research Institute, USA

  3. 5

    University of Cambridge, UK

Author Information

  1. 1

    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, USA

  2. 2

    Departments of Biological Chemistry and Internal Medicine, Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan, USA

Publication History

  1. Published Online: 2 JUL 2010
  2. Published Print: 9 JUN 2010

ISBN Information

Print ISBN: 9780471799283

Online ISBN: 9780470572702

SEARCH

Keywords:

  • endoplasmic reticulum stress and oxidative stress - mechanisms and links to disease;
  • sophisticated mechanisms, ensuring proper protein folding - and ER and oxidative protein folding;
  • ER stress and oxidative stress - clinical disease implications

Summary

This chapter contains sections titled:

  • Introduction

  • Protein Folding and Quality Control in the ER

  • UPR Signaling

  • Perk Phosphorylates eIF2α to Attenuate mRNA Translation

  • ATF6-Mediated Transcriptional Activation Requires Regulated Intramembrane Proteolysis

  • BIP is a Master Regulator of UPR Sensor Activation

  • ER and Oxidative Protein Folding

  • ER Stress and Oxidative Stress: Implications in Clinical Disease

  • Future Perspectives

  • References