Chapter 23. Islet Amyloid Polypeptide

  1. Marina Ramirez-Alvarado3,
  2. Jeffery W. Kelly4 and
  3. Christopher M. Dobson5
  1. Andisheh Abedini1 and
  2. Daniel P. Raleigh2

Published Online: 2 JUL 2010

DOI: 10.1002/9780470572702.ch23

Protein Misfolding Diseases: Current and Emerging Principles and Therapies

Protein Misfolding Diseases: Current and Emerging Principles and Therapies

How to Cite

Abedini, A. and Raleigh, D. P. (2010) Islet Amyloid Polypeptide, in Protein Misfolding Diseases: Current and Emerging Principles and Therapies (eds M. Ramirez-Alvarado, J. W. Kelly and C. M. Dobson), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470572702.ch23

Editor Information

  1. 3

    Mayo Clinic College of Medicine, USA

  2. 4

    The Scripps Research Institute, USA

  3. 5

    University of Cambridge, UK

Author Information

  1. 1

    Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York, USA

  2. 2

    Department of Chemistry, Graduate Program in Biochemistry and Structural Biology, State University of New York at Stony Brook, Stony Brook, New York, USA

Publication History

  1. Published Online: 2 JUL 2010
  2. Published Print: 9 JUN 2010

ISBN Information

Print ISBN: 9780471799283

Online ISBN: 9780470572702



  • islet amyloid polypeptide (IAPP) - in pancreases of patients with type 2 diabetes;
  • IAPP, role in maintaining glucose homeostasis - by suppression of insulin-mediated glucose uptake;
  • double-nucleation model - to rationalize IAPP fibrillization kinetics


This chapter contains sections titled:

  • Introduction

  • Normal Physiological Role of IAPP

  • Synthesis and Processing of IAPP

  • Not all Species Form Islet Amyloid

  • Aromatic Interactions and Amyloid Formation by IAPP and other Polypeptides

  • Structural Models of the IAPP Amyloid Protofilament

  • Kinetics of In Vitro Amyloid Formation by IAPP

  • Islet Amyloid Formation in Type 2 Diabetes and in Islet Cell Transplantation

  • IAPP Membrane Interactions

  • Helical Intermediates and Amyloid Formation by IAPP: A General Phenomenon?

  • Inhibitors of IAPP Amyloid Formation

  • ROLE of IAPP Analogs in the Treatment of Type 1 Diabetes

  • References