Chapter 44. Therapies Aimed at Controlling Gene Expression, Including up-Regulating a Chaperone or down-Regulating an Amyloidogenic Protein

  1. Marina Ramirez-Alvarado3,
  2. Jeffery W. Kelly4 and
  3. Christopher M. Dobson5
  1. Gregor P. Lotz1 and
  2. Paul J. Muchowski2

Published Online: 2 JUL 2010

DOI: 10.1002/9780470572702.ch44

Protein Misfolding Diseases: Current and Emerging Principles and Therapies

Protein Misfolding Diseases: Current and Emerging Principles and Therapies

How to Cite

Lotz, G. P. and Muchowski, P. J. (2010) Therapies Aimed at Controlling Gene Expression, Including up-Regulating a Chaperone or down-Regulating an Amyloidogenic Protein, in Protein Misfolding Diseases: Current and Emerging Principles and Therapies (eds M. Ramirez-Alvarado, J. W. Kelly and C. M. Dobson), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470572702.ch44

Editor Information

  1. 3

    Mayo Clinic College of Medicine, USA

  2. 4

    The Scripps Research Institute, USA

  3. 5

    University of Cambridge, UK

Author Information

  1. 1

    Gladstone Institute of Neurological Disease, University of California, San Francisco, California, USA

  2. 2

    Gladstone Institute of Neurological Disease, and Departments of Biochemistry and Biophysics, and Neurology, University of California, San Francisco, California, USA

Publication History

  1. Published Online: 2 JUL 2010
  2. Published Print: 9 JUN 2010

ISBN Information

Print ISBN: 9780471799283

Online ISBN: 9780470572702

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Keywords:

  • therapies aimed at controlling gene expression, up-regulating a chaperone or down-regulating an amyloidogenic protein;
  • molecular chaperones, facilitating protein folding under normal conditions;
  • HSR-inducing compounds - found in herbal medicine

Summary

This chapter contains sections titled:

  • Introduction

  • Molecular Chaperones: Function in Folding and Misfolding

  • Regulation of the HSR

  • Pharmacological Induction of the HSR

  • Down-Regulation of Amyloidogenic Protein Expression: Gene Silencing by RNA Interference as a Potential Therapeutic Approach for Protein Misfolding Diseases

  • Principles of RNAi

  • RNAi Therapy: Risks and Challenges

  • Conclusions

  • References